The effect of D-penicillamine on lung function parameters (diffusion capacity) in rheumatoid arthritis
Identifieur interne : 002E14 ( Main/Exploration ); précédent : 002E13; suivant : 002E15The effect of D-penicillamine on lung function parameters (diffusion capacity) in rheumatoid arthritis
Auteurs : J. Haerden [Belgique] ; L. Coolen ; J. DequekerSource :
- Clinical and experimental rheumatology [ 0392-856X ] ; 1993.
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- Pascal (Inist)
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- topic : Homme.
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Abstract
Sequential lung function tests were performed on 28 rheumatoid arthritis (RAj patients who were treated with D-penicillamine (total of 101 treatment years) and on 42 control RA patients who were not treated or who were treated with NSAIDs, chloroquine, gold salts, corticosteroids, salazopyrine or methotrexate. A decline in lung function parameters was found in both groups, although it was only significant for the carbon monoxide diffusing capacity corrected for lung volume (DLCO/VL). This decrease in DLCO/VL was less pronounced in the D-penicillamine group (mean-6.9%) than in the control group (mean-11.3%). This difference could not be attributed to smoking, which was more frequent in the control group
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